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We then performed a genome-wide survey of ac RPB1 occupancy and its influence on gene regulation in mice.
Genes with enrichment for ac RPB1 at their promoters and genes dysregulated when ac RPB1 was disrupted were specifically enriched for functions in growth-factor signaling, cell adhesion, vascular development, and cell-cell interaction.
The new CTD repeats introduced the potential for ac RPB1 due to the appearance of distal repeats with lysine at position seven.
This was followed by a further increase in the number of lysine-containing repeats in developmentally complex clades like Deuterostomia.
The number of CTD heptad repeats increased substantially in the ancestor of all Metazoa (31 to 44 repeats).
This was accompanied by the appearance of repeats with lysine at position seven (K CTD.) Thus, we conclude that CTD repeat length markedly increased with the origin of animals, and the distal repeats gained lysine residues and expanded further in different animal lineages.
The largest subunit, called RPB1, is unique to RNA polymerase II and is involved in its catalytic activity.
The C-terminal domain (CTD) of RPB1 is essential for the proper regulation of RNA polymerase II  and contains a protein-protein interaction surface for cofactors involved in the regulation of transcription initiation, elongation and RNA processing—highly specialized functions that determine the speed and reliability of the polymerase enzyme traversing a gene during transcription .
Disruption of this mechanism interfered with the expression of two growth-factor-induced genes regulated by polymerase pausing, but did not influence expression or polymerase occupancy at two non-paused genes [ residues, and thus the potential for RPB1 CTD acetylation, arose with animal multicellularity during an expansion in the overall number of CTD repeats in Metazoa.
Our phylogenetic analysis further showed that p300/KAT3B, the acetyltransferase that modifies the RPB1 CTD, was present at the appearance K-containing repeats.
Conserved heptad repeats are found in the linker-proximal part of the mammalian CTD, but the sequence of the distal heptad repeats, which are not present in yeast, diverge from this consensus sequence.Tags: Adult Dating, affair dating, sex dating