Sedating antihistamines wiki

Their main benefit is they primarily affect peripheral histamine receptors and therefore are less sedating.

Always read the leaflet that comes with your medicine to check it's safe for you before taking it or giving it to your child.

Antihistamines work by stopping a substance called histamine affecting the cells in your body.

receptor and heightens the receptor's activity; the receptor antagonists work by binding to the receptor and blocking the activation of the receptor by histamine; by comparison, the inverse agonists bind to the receptor and reduce its activity, an effect which is opposite to histamine's.-antihistamines can also reduce inflammation, since the expression of NF-κB, the transcription factor the regulates inflammatory processes, is promoted by both the receptor's constitutive activity and agonist (i.e., ; some may also have intrinsic analgesic properties of their own, orphenadrine being an example.

Second-generation antihistamines cross the blood–brain barrier to a much lower degree than the first-generation antihistamines.

Some antihistamines may not be suitable in these cases.

Your pharmacist or doctor can recommend one that's best for you.Antihistamines are medicines often used to relieve symptoms of allergies, such as hay fever, hives, conjunctivitis and reactions to insect bites or stings.They're also sometimes used to prevent motion sickness and as a short-term treatment for sleeping difficulties (insomnia).Most antihistamines can be bought from pharmacies and shops, but some are only available on prescription.They also come in several different forms – including tablets, capsules, liquids, syrups, creams, lotions, gels, eye drops and nasal sprays.There's not much evidence to suggest any particular antihistamine is better than any other at relieving allergy symptoms.

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