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Observational evidence can suggest association but is unable to make causative claims, though methods based on Mendelian randomisation are less prone to confounding.Interventional research, ideally in the form of randomised controlled trials, is essential before we can fully understand coffee’s potential to prevent specific health outcomes.Her beloved daughter, Tara, is the enthusiastic cook in the family, crafting memorable feasts for “two-to-a-crew” since adolescence.
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We searched Pub Med, Embase, CINAHL, and the Cochrane Database of Systematic Reviews from inception to July 2017 for meta-analyses of observational or interventional studies that investigated the association between coffee consumption and any health outcome.
We used the following search strategy: (coffee OR caffeine) AND (systematic review OR meta-analysis) using truncated terms for all fields, and following the SIGN guidance recommended search terms for systematic reviews and meta-analyses.12 Two researchers (RP and OJK) independently screened the titles and abstracts and selected articles for full text review.
Key active compounds include caffeine, chlorogenic acids, and the diterpenes, cafestol and kahweol.
The biochemistry of coffee has been documented extensively elsewhere.4 Coffee undergoes a chemical metamorphosis from the unroasted green bean, and the type of bean (Arabica versus Robusta), degree of roasting, and preparation method including coffee grind setting and brew type, will all have an influence on the biochemical composition of the final cup.567 An individual’s genotype and gut microbiome will then determine the bioavailability and type of coffee metabolites to which that individual is exposed.8Existing research has explored the associations between coffee as an exposure and a range of outcomes including all cause mortality, cancer, and diseases of the cardiovascular, metabolic, neurological, musculoskeletal, gastrointestinal, and liver systems, as well as outcomes associated with pregnancy.
High versus low consumption was associated with an 18% lower risk of incident cancer (0.82, 0.74 to 0.89).Tags: Adult Dating, affair dating, sex dating