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The forces of the time vortex began to destroy every cell in his body, and he had to regenerate to save his life.

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(TV: Time Crash) Mawdryn attempted to force the Fifth Doctor to use up his eight remaining regenerations to end his follower's cycle of perpetual rebirth, but this was rendered unnecessary when Alistair Gordon Lethbridge-Stewart made physical contact with his younger self and a discharge of temporal energy was released that allowed Mawdryn and his followers to die.

(TV: Mawdryn Undead) After the TARDIS became "stalled in the equivalent of a galactic lay-by", the Sixth Doctor had a worried thought of Peri Brown growing old and dying in the TARDIS, while he would "go on regenerating until all [his] lives [were] spent." (TV: Vengeance on Varos) When the Master exposed the Valeyard's alliance with High Council to the Sixth Doctor at his trial, he revealed that the Valeyard was acting as the prosecutor for the trial in exchange for the Doctor's remaining regenerations.

Indeed, the Tenth Doctor was described by the Moment as "the man who regrets".

The fact that he was instantly able to recall the number of Gallifreyan children that he believed had been killed during the war indicated just how keenly he actually felt those horrendous memories.

(TV: The Ultimate Foe) When Ace was sent into the Seventh Doctor's mind, she discovered a room with thirteen cubicles, seven of them empty, while the other six contained shadowy white figures, representing the Doctor's future incarnations.

(PROSE: Timewyrm: Revelation) After sealing Gallifrey away in a pocket dimension, (TV: The Day of the Doctor) the Seventh Doctor was able to recall teaming up with his other twelve incarnations to save Gallifrey.

He met his eventual end after he absorbed a huge quantity of nuclear radiation whilst saving the life of Donna Noble's grandfather, Wilfred Mott.

Delaying the process to visit all of his companions, the Doctor finally regenerated in the TARDIS, causing a huge amount of damage due to delaying the regeneration for as long as he did and leaving his successor crashing straight for Earth.

The First Doctor was shown footage of the Tenth Doctor, as well as his ten other successors, by the Testimony when he expressed doubt over the Twelfth Doctor's identity.

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