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The political situation in Germany and elsewhere in Europe after World War I (1914–1918) contributed to the rise of virulent antisemitism.Many Germans did not accept that their country had been defeated, which gave birth to the stab-in-the-back myth.

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Donald Niewyk and Francis Nicosia, in The Columbia Guide to the Holocaust (2000), favour a definition that focuses on the Jews, Roma, and Aktion T4 victims: "the systematic, state-sponsored murder of entire groups determined by heredity.

This applied to Jews, Gypsies, and the handicapped." The logistics of the mass murder turned the country into what Michael Berenbaum called "a genocidal state".

This perception contributed to the canard of Jewish Bolshevism.

The economic strains of the Great Depression led some in the German medical establishment to advocate the euthanasia of the "incurable" mentally and physically disabled as a cost-saving measure to free up funds for the curable.

The second half of the 19th century saw the emergence in the German empire and Austria-Hungary of the völkisch movement, which was developed by such thinkers as Houston Stewart Chamberlain and Paul de Lagarde.

The movement embraced a pseudo-scientific racism that viewed Jews as a race whose members were locked in mortal combat with the Aryan race for world domination.Throughout the Middle Ages in Europe, Jews were subjected to antisemitism based on Christian theology, which blamed them for killing Jesus.Even after the Reformation, Catholicism and Lutheranism continued to persecute Jews, accusing them of blood libels and subjecting them to pogroms and expulsions.This is thought to refer to Mengele's academic supervisor, Otmar von Verschuer, director from October 1942 of the Kaiser Wilhelm Institute of Anthropology, Human Heredity, and Eugenics in Berlin-Dahlem.Mengele's experiments included placing subjects in pressure chambers, testing drugs on them, freezing them, attempting to change their eye color by injecting chemicals into children's eyes, and amputations and other surgeries.Experiments took place at Auschwitz, Buchenwald, Dachau, Natzweiler, Neuengamme, Ravensbrück, Sachsenhausen, and elsewhere.

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